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Glutathione suppresses tyrosinase in three ways: direct inhibition through chelation of copper, interference with the transfer of tyrosinase to premelanosomes, tyrosinase inhibition indirectly by antioxidant effect

N-acetyl-cysteine administration supplies the cysteine necessary for GSH synthesis and concomitantly reduces hyperhomocysteinemia, improving GSH peroxidase activity and reducing oxidative stress (159)

This vicious cycle is critically amplified by the involvement of non-neuronal cells, primarily microglia and astrocytes

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Previous in vitro research has revealed that supplementation of GSH at a concentration of 5 mM to H

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